Incidence of Mucocutaneous Reactions in Children Treated With Niflumic Acid, Other Nonsteroidal Antiinflammatory Drugs, or Nonopioid Analgesics

Incidence of mucocutaneous reactions in children treated with niflumic acid, other nonsteroidal antiinflammatory drugs, or nonopioid analgesics.

BACKGROUND AND OBJECTIVE Results from a relatively small case-control study recently showed that niflumic acid increases the risk of serious mucocutaneous reactions in children. As a consequence, the Italian Ministry of Health sent a "Dear Doctor" letter in June 2001 to warn pediatricians about the alleged adverse effects. The objective of this study was to estimate and compare the incidence of...

Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs.

Use of Nonsteroidal Antiinflammatory Drugs

Clinical trial data have prompted questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. Since the 2005 publication of a Science Advisory on the use of nonsteroidal antiinflammatory drugs (NSAIDs) by the American Heart Association,1 several important events have o...

Colonic side effects of nonsteroidal antiinflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are a widely prescribed group of drugs, known to be responsible for many cases of gastroduodenal ulcers by inhibiting cyclo-oxygenase (1). The incidence of side effects while taking NSAID therapy is high, and has been reported to approach 70% in patients receiving long-term therapy. The most frequent complications are those involving the gastroduod...

Opioid and Nonopioid Analgesics